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Hidehiko Nakagawa Selected Research

Neoplasms (Cancer)

1/2022FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
1/2021Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors.
1/2021Live-Cell Imaging of Sirtuin Activity Using a One-Step Fluorescence Probe.
9/2020Synthesis of artificial substrate based on inhibitor for detecting LSD1 activity.
11/2019Ratiometric assay of CARM1 activity using a FRET-based fluorescent probe.
10/2019Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer.
1/2019An irreversible inhibitor of peptidyl-prolyl cis/trans isomerase Pin1 and evaluation of cytotoxicity.
1/2017Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets.
10/2016A Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of the Dabcyl Quencher.
2/2016Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.
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Hidehiko Nakagawa Research Topics

Disease

17Neoplasms (Cancer)
01/2022 - 02/2005
6Colonic Neoplasms (Colon Cancer)
01/2016 - 05/2009
2Prostatic Neoplasms (Prostate Cancer)
01/2022 - 01/2019
2Metabolic Diseases (Metabolic Disease)
01/2021 - 10/2016
2Alzheimer Disease (Alzheimer's Disease)
11/2016 - 01/2016
2T-Cell Lymphoma (Lymphoma, T Cell)
03/2014 - 11/2012
2Breast Neoplasms (Breast Cancer)
11/2007 - 08/2007
1Neoplasm Metastasis (Metastasis)
01/2020
1Fibrosis (Cirrhosis)
01/2020
1Bites and Stings (Sting)
10/2019
1Glioblastoma (Glioblastoma Multiforme)
10/2019
1Triple Negative Breast Neoplasms
10/2019
1Insulin Resistance
10/2019
1Rheumatoid Arthritis
01/2018
1Erectile Dysfunction
01/2016
1Inflammation (Inflammations)
01/2015
1Neuroblastoma
11/2012
1Parkinson Disease (Parkinson's Disease)
06/2012
1Huntington Disease (Huntington's Disease)
06/2012
1Neurodegenerative Diseases (Neurodegenerative Disease)
06/2012
1Carcinogenesis
12/2010
1Cardiovascular Diseases (Cardiovascular Disease)
03/2007
1Brain Ischemia (Cerebral Ischemia)
03/2007
1Hepatocellular Carcinoma (Hepatoma)
07/2005
1Liver Diseases (Liver Disease)
07/2005

Drug/Important Bio-Agent (IBA)

5EnzymesIBA
01/2020 - 02/2005
3Histones (Histone)IBA
01/2018 - 02/2005
3Sirtuin 1IBA
10/2009 - 05/2009
2LigandsIBA
01/2022 - 10/2019
2SirtuinsIBA
01/2021 - 10/2016
2Biological ProductsIBA
09/2020 - 06/2012
2Antineoplastic Agents (Antineoplastics)IBA
01/2019 - 09/2013
2Amyloid (Amyloid Fibrils)IBA
11/2016 - 01/2016
2Lysine (L-Lysine)FDA Link
02/2016 - 08/2010
2Histone DemethylasesIBA
02/2016 - 08/2010
2Coloring Agents (Dyes)IBA
04/2011 - 04/2011
2Histone Deacetylases (Histone Deacetylase)IBA
11/2007 - 02/2005
1tacrolimus binding protein 4 (FKBP52)IBA
01/2022
1Tacrolimus (Prograf)FDA LinkGeneric
01/2022
1Transcription Factors (Transcription Factor)IBA
01/2022
1Androgen Receptors (Androgen Receptor)IBA
01/2022
1Prostate-Specific Antigen (Semenogelase)IBA
01/2022
1Peptidylprolyl Isomerase (Prolyl Isomerase)IBA
01/2022
1CaspasesIBA
01/2021
1Lysophosphatidic Acid ReceptorsIBA
01/2020
1lysophosphatidic acidIBA
01/2020
1coactivator-associated arginine methyltransferase 1IBA
11/2019
1Glycoproteins (Glycoprotein)IBA
10/2019
1Biomarkers (Surrogate Marker)IBA
10/2019
1ectonucleotide pyrophosphatase phosphodiesterase 1IBA
10/2019
1Messenger RNA (mRNA)IBA
10/2019
1EstersIBA
01/2019
1Cyclin D1IBA
01/2019
1Peptide Hydrolases (Proteases)FDA Link
01/2019
1IsoenzymesIBA
01/2018
14,6-dinitro-o-cresol (DNOC)IBA
02/2016
1Protein AggregatesIBA
01/2016
16- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA
01/2016
1Indicators and Reagents (Reagents)IBA
01/2016
1Peptides (Polypeptides)IBA
01/2016
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
01/2015
1N- hydroxy- 3- (1- (phenylthio)methyl- 1H- 1,2,3- triazol- 4- yl)benzamideIBA
03/2014
1methyl-lysineIBA
09/2013
1CohesinsIBA
11/2012
1TubulinIBA
06/2012
1Sirtuin 2IBA
06/2012
1mitotracker green FMIBA
04/2011
1DNA (Deoxyribonucleic Acid)IBA
12/2010
1oxalylglycineIBA
08/2010
1Proteins (Proteins, Gene)FDA Link
08/2010
1ProdrugsIBA
08/2010
1Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
08/2010
1Estrogens (Estrogen)FDA Link
11/2007
1Paclitaxel (Taxol)FDA LinkGeneric
11/2007
1Estrogen Receptor alphaIBA
11/2007
1Folic Acid (Vitamin M)FDA LinkGeneric
08/2007
1LipidsIBA
03/2007
1CopperIBA
07/2005
1Superoxide DismutaseIBA
07/2005
1MetallothioneinIBA
07/2005
1ZincIBA
07/2005

Therapy/Procedure

4Therapeutics
01/2017 - 09/2013